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Issue 4, 2018
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A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

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Abstract

Herein, we report a unique siRNA-induced peptide co-assembly nanocarrier, which could efficiently co-assemble upon the addition of siRNA, forming nanospheres with high biocompatibility and transfection efficiency both in vitro and in vivo. In a tumor xenograft nude mouse model, these siRNA–peptide nanospheres inhibited tumor volume growth by >60%.

Graphical abstract: A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

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Publication details

The article was received on 02 Apr 2018, accepted on 06 Jun 2018 and first published on 06 Jun 2018


Article type: Communication
DOI: 10.1039/C8MH00392K
Citation: Mater. Horiz., 2018,5, 745-752
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    A siRNA-induced peptide co-assembly system as a peptide-based siRNA nanocarrier for cancer therapy

    W. Li, D. Wang, X. Shi, J. Li, Y. Ma, Y. Wang, T. Li, J. Zhang, R. Zhao, Z. Yu, F. Yin and Z. Li, Mater. Horiz., 2018, 5, 745
    DOI: 10.1039/C8MH00392K

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