Issue 2, 2015

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Abstract

Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo.

Graphical abstract: Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

Supplementary files

Article information

Article type
Concise Article
Submitted
08 Oct 2014
Accepted
11 Nov 2014
First published
12 Nov 2014

Med. Chem. Commun., 2015,6, 357-362

Synthetic spirocyclic endoperoxides: new antimalarial scaffolds

M. Brindisi, S. Gemma, S. Kunjir, L. Di Cerbo, S. Brogi, S. Parapini, S. D'Alessandro, D. Taramelli, A. Habluetzel, S. Tapanelli, S. Lamponi, E. Novellino, G. Campiani and S. Butini, Med. Chem. Commun., 2015, 6, 357 DOI: 10.1039/C4MD00454J

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