Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseases

Abstract

We report the investigation of the molecular mechanisms responsible for the neuroprotective activity of water-soluble [60]fullerene derivatives (WS[60]FDs). It has been shown that WS[60]FDs influence the therapeutically important targets of the Alzheimer disease by inhibiting the catalytic activity of the monoaminooxidase B in vitro, decreasing the level of free radical species and behaving as positive modulators of AMPA receptors of Purkinje neurons in the cerebellum of rats. The cognitive stimulatory effects of WS[60]FDs were revealed in vivo through behavioural experiments in mice.