Jump to main content
Jump to site search

Issue 6, 2014
Previous Article Next Article

Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells

Author affiliations

Abstract

The antiproliferative and differentiation potential of anthocyanin-rich strawberry fruit crude extracts (SE) were investigated on B16-F10 murine melanoma cells. Treatment of melanoma cells with SE produced a remarkable reduction of cell proliferation, paralleled with both the lowering of the intracellular levels of polyamine, and the enhancement of tissue transglutaminase (TG2, EC 2.3.2.13) activity (used as a differentiation marker). To gain further insight into profiling altered protein expression as a potential biomarker of the SE action on melanoma cells, analysis of the proteomic profile was performed on the treated B16-F10 cells, compared to the control. Following SE treatment, 30 proteins resulted up-regulated, and 87 proteins were down-regulated. In particular proteins overexpressed in cancer cells, involved in tumor progression and metabolism, were down-regulated. The possibility that SE may affect the Warburg effect in B16-F10 melanoma cells is discussed.

Graphical abstract: Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 29 Jul 2013, accepted on 18 Oct 2013 and first published on 18 Oct 2013


Article type: Paper
DOI: 10.1039/C3MB70316A
Citation: Mol. BioSyst., 2014,10, 1255-1263
  •   Request permissions

    Antineoplastic activity of strawberry (Fragaria × ananassa Duch.) crude extracts on B16-F10 melanoma cells

    C. Forni, R. Braglia, N. Mulinacci, A. Urbani, M. Ronci, A. Gismondi, C. Tabolacci, B. Provenzano, A. Lentini and S. Beninati, Mol. BioSyst., 2014, 10, 1255
    DOI: 10.1039/C3MB70316A

Search articles by author