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Issue 16, 2014
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A smartphone-based chip-scale microscope using ambient illumination

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Abstract

Portable chip-scale microscopy devices can potentially address various imaging needs in mobile healthcare and environmental monitoring. Here, we demonstrate the adaptation of a smartphone's camera to function as a compact lensless microscope. Unlike other chip-scale microscopy schemes, this method uses ambient illumination as its light source and does not require the incorporation of a dedicated light source. The method is based on the shadow imaging technique where the sample is placed on the surface of the image sensor, which captures direct shadow images under illumination. To improve the image resolution beyond the pixel size, we perform pixel super-resolution reconstruction with multiple images at different angles of illumination, which are captured while the user is manually tilting the device around any ambient light source, such as the sun or a lamp. The lensless imaging scheme allows for sub-micron resolution imaging over an ultra-wide field-of-view (FOV). Image acquisition and reconstruction are performed on the device using a custom-built Android application, constructing a stand-alone imaging device for field applications. We discuss the construction of the device using a commercial smartphone and demonstrate the imaging capabilities of our system.

Graphical abstract: A smartphone-based chip-scale microscope using ambient illumination

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Publication details

The article was received on 02 May 2014, accepted on 27 May 2014, published on 27 May 2014 and first published online on 27 May 2014


Article type: Paper
DOI: 10.1039/C4LC00523F
Citation: Lab Chip, 2014,14, 3056-3063
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    A smartphone-based chip-scale microscope using ambient illumination

    S. A. Lee and C. Yang, Lab Chip, 2014, 14, 3056
    DOI: 10.1039/C4LC00523F

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