Issue 2, 2015

Development of GSK's acid and base selection guides

Abstract

Further to the introduction of solvent and reagent guides at GSK, the reagent guide methodology has been adapted to score common acids and bases for use in situations where the chemistry is tolerant of a number of options. The pKa of each acid and base, and information as to whether they are generally recognised as safe are included to enhance the utility of such guides.

Graphical abstract: Development of GSK's acid and base selection guides

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2014
Accepted
24 Sep 2014
First published
25 Sep 2014

Green Chem., 2015,17, 945-949

Author version available

Development of GSK's acid and base selection guides

R. K. Henderson, A. P. Hill, A. M. Redman and H. F. Sneddon, Green Chem., 2015, 17, 945 DOI: 10.1039/C4GC01481B

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