Issue 44, 2014
From the journal:

Dalton Transactions

Mitochondria-targeting phosphorescent iridium(iii) complexes for living cell imaging†

Qingqing Zhang,‡abc   Rui Cao,‡ab   Hao Feia  and  Ming Zhou*ad  

* Corresponding authors

a Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China
E-mail: mzhou2007@sinano.ac.cn

b University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing, P. R. China

c Institute of Chemistry, Chinese Academy of Sciences, 2 Zhongguancun North First Street, Beijing 100190, P. R. China

d SunaTech Inc., bioBAY, Suzhou Industrial Park, Suzhou, Jiangsu, P. R. China

Abstract

Two phosphorescent iridium(III) complexes conjugated to a lipophilic triphenylphosphonium cation moiety, IrMitoOlivine and IrMitoNIR, were synthesized. The complexes show high mitochondria-specificity and relatively lower cytotoxicity. Time-lapse confocal imaging indicates that both complexes exhibit an excellent anti-photobleaching capability under continuous laser irradiation.

Graphical abstract: Mitochondria-targeting phosphorescent iridium(iii) complexes for living cell imaging

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Article information

DOI
https://doi.org/10.1039/C4DT00823E
Article type
Paper
Submitted
19 Mar 2014
Accepted
24 Aug 2014
First published
15 Sep 2014

Dalton Trans., 2014,43, 16872-16879

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Mitochondria-targeting phosphorescent iridium(III) complexes for living cell imaging

Q. Zhang, R. Cao, H. Fei and M. Zhou, Dalton Trans., 2014, 43, 16872 DOI: 10.1039/C4DT00823E

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