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Issue 9, 2014
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Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes

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Abstract

We describe herein highly effective asymmetric hydrogenation of quinolines in undegassed water catalyzed by chiral cationic Ru-diamine complexes for the first time. This facile and green protocol is applicable to the scaled-up synthesis of 6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline, a key intermediate for the preparation of the antibacterial agent (S)-flumequine, with 98% ee.

Graphical abstract: Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes

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Publication details

The article was received on 04 Apr 2014, accepted on 09 May 2014 and first published on 09 May 2014


Article type: Communication
DOI: 10.1039/C4CY00418C
Author version available: Download Author version (PDF)
Citation: Catal. Sci. Technol., 2014,4, 2887-2890
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    Efficient asymmetric hydrogenation of quinolines in neat water catalyzed by chiral cationic Ru-diamine complexes

    Z. Yang, F. Chen, Y. He, N. Yang and Q. Fan, Catal. Sci. Technol., 2014, 4, 2887
    DOI: 10.1039/C4CY00418C

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