Jump to main content
Jump to site search

Issue 7, 2014
Previous Article Next Article

Synthesis of new derivatives of copper complexes of Josiphos family ligands for applications in asymmetric catalysis

Author affiliations

Abstract

A series of new copper complexes containing chiral ferrocenyl diphosphine ligands of the Josiphos family have been prepared. These complexes have been studied in the catalytic asymmetric 1,2-addition of Grignard reagents to enones and aromatic ketones. Variation of the electronic and steric properties of the ligand resulted in a positive effect in the regio- and enantioselectivity of Grignard reagents to α-H-substituted enones using the ligand in which tert-butyl substituents were introduced in the diarylphosphine moiety. The copper complexes were also successfully applied in the catalytic asymmetric conjugate addition of Grignard reagents to enoates. No increase of enantioselectivity was observed in the catalytic asymmetric addition of linear Grignard reagents, compared to that of the commercially available ligand rev-Josiphos.

Graphical abstract: Synthesis of new derivatives of copper complexes of Josiphos family ligands for applications in asymmetric catalysis

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Feb 2014, accepted on 23 Mar 2014 and first published on 24 Mar 2014


Article type: Paper
DOI: 10.1039/C4CY00180J
Citation: Catal. Sci. Technol., 2014,4, 1997-2005
  • Open access: Creative Commons BY license
  •   Request permissions

    Synthesis of new derivatives of copper complexes of Josiphos family ligands for applications in asymmetric catalysis

    R. Oost, J. Rong, A. J. Minnaard and S. R. Harutyunyan, Catal. Sci. Technol., 2014, 4, 1997
    DOI: 10.1039/C4CY00180J

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements