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Issue 18, 2014
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Natural and engineered biosynthesis of fluorinated natural products

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Abstract

Both natural products and synthetic organofluorines play important roles in the discovery and design of pharmaceuticals. The combination of these two classes of molecules has the potential to be useful in the ongoing search for new bioactive compounds but our ability to produce site-selectively fluorinated natural products remains limited by challenges in compatibility between their high structural complexity and current methods for fluorination. Living systems provide an alternative route to chemical fluorination and could enable the production of organofluorine natural products through synthetic biology approaches. While the identification of biogenic organofluorines has been limited, the study of the native organisms and enzymes that utilize these compounds can help to guide efforts to engineer the incorporation of this unusual element into complex pharmacologically active natural products. This review covers recent advances in understanding both natural and engineered production of organofluorine natural products.

Graphical abstract: Natural and engineered biosynthesis of fluorinated natural products

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Publication details

The article was received on 16 Jan 2014 and first published on 28 Apr 2014


Article type: Review Article
DOI: 10.1039/C4CS00027G
Author version available: Download Author version (PDF)
Citation: Chem. Soc. Rev., 2014,43, 6527-6536
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    Natural and engineered biosynthesis of fluorinated natural products

    M. C. Walker and M. C. Y. Chang, Chem. Soc. Rev., 2014, 43, 6527
    DOI: 10.1039/C4CS00027G

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