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Issue 18, 2014
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Addition of CF3 across unsaturated moieties: a powerful functionalization tool

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Abstract

In the last few years, the efficient introduction of trifluoromethyl groups in organic molecules has become a major research focus. This review highlights the recent developments enabling the incorporation of CF3 groups across unsaturated moieties, preferentially alkenes, and the mechanistic scenarios governing these transformations. We have specially focused on methods involving the simultaneous formation of C–CF3 and C–C or C–heteroatom bonds by formal addition reactions across π-systems, as such difunctionalization processes hold valuable synthetic potential.

Graphical abstract: Addition of CF3 across unsaturated moieties: a powerful functionalization tool

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Publication details

The article was received on 15 Jan 2014 and first published on 02 May 2014


Article type: Review Article
DOI: 10.1039/C4CS00025K
Citation: Chem. Soc. Rev., 2014,43, 6598-6608
  • Open access: Creative Commons BY license
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    Addition of CF3 across unsaturated moieties: a powerful functionalization tool

    E. Merino and C. Nevado, Chem. Soc. Rev., 2014, 43, 6598
    DOI: 10.1039/C4CS00025K

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