Jump to main content
Jump to site search

Issue 13, 2014
Previous Article Next Article

Navigating the cell: how motors overcome roadblocks and traffic jams to efficiently transport cargo

Author affiliations

Abstract

Intracellular transport plays an essential role in maintaining the organization of cells. The importance of long-range, bi-directional transport is evidenced by the fact that its failure goes hand in hand with several diseases including neurodegenerative diseases such as Alzheimer's and Amyotrophic Lateral Sclerosis. The nanoscale cellular transport machinery consisting of cytoskeletal tracks and motor-proteins is responsible for effectively delivering important materials to specific locations inside the cell. Motor-proteins manage to overcome several challenges in the crowded cellular environment to achieve well-coordinated and effective transport. In recent years, thanks to state-of-the-art single molecule biophysical tools, we have started to gain insights into the cellular traffic rules. This perspective summarizes the challenges that motors face in navigating the complex cytoskeleton and the lessons learned about transport in crowded environments from both bottom-up in vitro studies as well as top-down in vivo studies.

Graphical abstract: Navigating the cell: how motors overcome roadblocks and traffic jams to efficiently transport cargo

Back to tab navigation

Publication details

The article was received on 13 Dec 2013, accepted on 04 Feb 2014 and first published on 04 Feb 2014


Article type: Perspective
DOI: 10.1039/C3CP55271C
Citation: Phys. Chem. Chem. Phys., 2014,16, 5907-5916
  •   Request permissions

    Navigating the cell: how motors overcome roadblocks and traffic jams to efficiently transport cargo

    M. Lakadamyali, Phys. Chem. Chem. Phys., 2014, 16, 5907
    DOI: 10.1039/C3CP55271C

Search articles by author

Spotlight

Advertisements