A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate†
Abstract
Cocrystallisation of sildenafil with acetylsalicylic acid yields a 1 : 1 sildenafil–acetylsalicylic-acid cocrystal, as well as a 1 : 1 : 1 cocrystal salt involving a sildenafil cation, acetylsalicylate and salicylic acid. The 1 : 1 acetylsalicylic-acid-based cocrystal exhibits an enhanced intrinsic dissolution rate, as compared to sildenafil citrate (the active ingredient of Viagra®).