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Issue 1, 2014
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A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

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Abstract

Cocrystallisation of sildenafil with acetylsalicylic acid yields a 1 : 1 sildenafil–acetylsalicylic-acid cocrystal, as well as a 1 : 1 : 1 cocrystal salt involving a sildenafil cation, acetylsalicylate and salicylic acid. The 1 : 1 acetylsalicylic-acid-based cocrystal exhibits an enhanced intrinsic dissolution rate, as compared to sildenafil citrate (the active ingredient of Viagra®).

Graphical abstract: A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

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Publication details

The article was received on 12 Apr 2013, accepted on 09 Oct 2013 and first published on 09 Oct 2013


Article type: Communication
DOI: 10.1039/C3CE42013B
Citation: CrystEngComm, 2014,16, 32-35
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    A sildenafil cocrystal based on acetylsalicylic acid exhibits an enhanced intrinsic dissolution rate

    M. Žegarac, E. Lekšić, P. Šket, J. Plavec, M. Devčić Bogdanović, D. Bučar, M. Dumić and E. Meštrović, CrystEngComm, 2014, 16, 32
    DOI: 10.1039/C3CE42013B

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