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Issue 65, 2017
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A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

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Abstract

A chemoselective tandem reaction of a multi-reactive, two electrophile + two nucleophile, system is reported. An allylation/cross-coupling process of a haloaryl aldehyde, an aryl BPin, and an allyl BPin can be controlled using a temperature gradient to overcome natural reactivity profiles and allow two sequential chemoselective C–C bond formations without intervention. This process offers efficient access to an array of functionalised products including pharmaceutical and natural product scaffolds.

Graphical abstract: A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

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Publication details

The article was received on 13 Jul 2017, accepted on 26 Jul 2017 and first published on 26 Jul 2017


Article type: Communication
DOI: 10.1039/C7CC05416E
Citation: Chem. Commun., 2017,53, 9139-9142
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    A one-pot tandem chemoselective allylation/cross-coupling via temperature control of a multi-nucleophile/electrophile system

    C. Xu, J. W. B. Fyfe, C. P. Seath, S. H. Bennett and A. J. B. Watson, Chem. Commun., 2017, 53, 9139
    DOI: 10.1039/C7CC05416E

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