Issue 65, 2015

Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

Graphical abstract: Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Supplementary files

Article information

Article type
Communication
Submitted
05 Jun 2015
Accepted
07 Jul 2015
First published
08 Jul 2015
This article is Open Access
Creative Commons BY license

Chem. Commun., 2015,51, 12977-12980

Author version available

Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

D. E. Mitchell, N. R. Cameron and M. I. Gibson, Chem. Commun., 2015, 51, 12977 DOI: 10.1039/C5CC04647E

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