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Issue 65, 2015
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Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

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Abstract

Antifreeze (glyco) proteins AF(G)Ps are potent ice recrystallization inhibitors, which is a desirable property to enhance cryopreservation of donor tissue/cells. Here we present the rational synthesis of a new, biomimetic, ice-recrystallization inhibiting polymer derived from a cheap commodity polymer, based on an ampholyte structure. The polymer is used to enhance the cryopreservation of red blood cells, demonstrating a macromolecular solution to tissue storage.

Graphical abstract: Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

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Publication details

The article was received on 05 Jun 2015, accepted on 07 Jul 2015 and first published on 08 Jul 2015


Article type: Communication
DOI: 10.1039/C5CC04647E
Citation: Chem. Commun., 2015,51, 12977-12980
  • Open access: Creative Commons BY license
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    Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

    D. E. Mitchell, N. R. Cameron and M. I. Gibson, Chem. Commun., 2015, 51, 12977
    DOI: 10.1039/C5CC04647E

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