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Issue 10, 2015
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Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

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Abstract

We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.

Graphical abstract: Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

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Publication details

The article was received on 09 Oct 2014, accepted on 03 Dec 2014 and first published on 03 Dec 2014


Article type: Communication
DOI: 10.1039/C4CC07911F
Citation: Chem. Commun., 2015,51, 1866-1869
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    Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

    C. W. T. Leung, F. Guo, Y. Hong, E. Zhao, R. T. K. Kwok, N. L. C. Leung, S. Chen, N. N. Vaikath, O. M. El-Agnaf, Y. Tang, W. Gai and B. Z. Tang, Chem. Commun., 2015, 51, 1866
    DOI: 10.1039/C4CC07911F

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