Issue 10, 2015

Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

Abstract

We report a fluorophore, TPE-TPP, with AIE characteristics which is utilized as a fluorescence probe to monitor the α-synuclein (α-Syn) fibrillation process. Compared with ThT, TPE-TPP shows a higher sensitivity in the detection of α-Syn oligomers as well as fibrils with a stronger fluorescence. The performance of TPE-TPP was evaluated using fluorescence, AFM, dot blot, and SEC.

Graphical abstract: Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

Supplementary files

Article information

Article type
Communication
Submitted
09 Oct 2014
Accepted
03 Dec 2014
First published
03 Dec 2014

Chem. Commun., 2015,51, 1866-1869

Detection of oligomers and fibrils of α-synuclein by AIEgen with strong fluorescence

C. W. T. Leung, F. Guo, Y. Hong, E. Zhao, R. T. K. Kwok, N. L. C. Leung, S. Chen, N. N. Vaikath, O. M. El-Agnaf, Y. Tang, W. Gai and B. Z. Tang, Chem. Commun., 2015, 51, 1866 DOI: 10.1039/C4CC07911F

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