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Issue 16, 2015
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A robust and modular synthesis of ynamides

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Abstract

A flexible, modular ynamide synthesis is reported that uses trichloroethene as an inexpensive two carbon synthon. A wide range of amides and electrophiles can be converted to the corresponding ynamides, importantly including acyclic carbamates, hindered amides, and aryl amides. This method thus overcomes many of the limitations of other approaches to this useful functionality.

Graphical abstract: A robust and modular synthesis of ynamides

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Publication details

The article was received on 07 Oct 2014, accepted on 29 Oct 2014 and first published on 06 Nov 2014


Article type: Communication
DOI: 10.1039/C4CC07876D
Citation: Chem. Commun., 2015,51, 3316-3319
  • Open access: Creative Commons BY license
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    A robust and modular synthesis of ynamides

    S. J. Mansfield, C. D. Campbell, M. W. Jones and E. A. Anderson, Chem. Commun., 2015, 51, 3316
    DOI: 10.1039/C4CC07876D

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