Issue 96, 2014
From the journal:

Chemical Communications

Bismuth(iii) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6]†

Amita Pathak,a   Victoria L. Blair,a   Richard L. Ferrero,b   Michael Mehringc  and  Philip C. Andrews*a  

* Corresponding authors

a School of Chemistry, Monash University, Clayton, Melbourne, Australia
E-mail: phil.andrews@monash.edu

b MIMR-PHI Institute of Medical Research, Centre for Innate Immunity and Infectious Diseases Monash University, Clayton, Melbourne, Australia

c Fakultät für Naturwissenschaften, Institut für Chemie, Professur Koordinationschemie, Technische Universität Chemnitz, 09107 Chemnitz, Germany

Abstract

Reaction of BiPh3 or Bi(OtBu)3 with benzohydroxamic acid (H2-BHA) results in formation of novel mono- and di-anionic hydroxamato complexes; [Bi2(BHA)3]∞1, [Bi(H-BHA)3] 2, [Bi(BHA)(H-BHA)] 3, all of which display nM activity against Helicobacter pylori. Subsequent dissolution of [Bi2(BHA)3]∞ in DMSO/toluene results in hydrolysis to the first structurally authenticated {Bi34} oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6] 4.

Graphical abstract: Bismuth(iii) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6]

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Article information

DOI
https://doi.org/10.1039/C4CC07329K
Article type
Communication
Submitted
17 Sep 2014
Accepted
17 Oct 2014
First published
17 Oct 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 15232-15234

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Bismuth(III) benzohydroxamates: powerful anti-bacterial activity against Helicobacter pylori and hydrolysis to a unique Bi34 oxido-cluster [Bi34O22(BHA)22(H-BHA)14(DMSO)6]

A. Pathak, V. L. Blair, R. L. Ferrero, M. Mehring and P. C. Andrews, Chem. Commun., 2014, 50, 15232 DOI: 10.1039/C4CC07329K

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