Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins

Yuzhou Wu; Chuang Li; Felix Boldt; Yanran Wang; Seah Ling Kuan; Thuy Tam Tran; Viktoria Mikhalevich; Christina Förtsch; Holger Barth; Zhongqiang Yang; Dongsheng Liu; Tanja Weil

doi:10.1039/C4CC07144A

Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins†

Yuzhou Wu,‡*^a Chuang Li,‡^b Felix Boldt,^a Yanran Wang,^a Seah Ling Kuan,^a Thuy Tam Tran,^a Viktoria Mikhalevich,^a Christina Förtsch,^c Holger Barth,^c Zhongqiang Yang,^b Dongsheng Liu*^b and Tanja Weil*^a

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* Corresponding authors

^a Institute of Organic Chemistry III, Macromolecular Chemistry and Biomaterials, University of Ulm, Albert-Einstein-Allee 11, D-89081 Ulm, Germany
E-mail: yuzhou.wu@uni-ulm.de, tanja.weil@uni-ulm.de

^b Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, China
E-mail: liudongsheng@tsinghua.edu.cn

^c Institute of Pharmacology and Toxicology, University of Ulm Medical Center, Albert-Einstein-Allee 11, D-89081 Ulm, Germany

Abstract

A modular approach for the precise assembly of multi-component hydrogels consisting of protein and DNA building blocks is described for the first time. Multi-arm DNA is designed for crosslinking and stepwise, non-covalent assembly of active proteins inside the hydrogel.

Chemical Communications

Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins†

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Programmable protein–DNA hybrid hydrogels for the immobilization and release of functional proteins

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