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Issue 95, 2014
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Inducing achiral aliphatic oligoureas to fold into helical conformations

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Abstract

The ability of urea-linked oligomers of achiral diamines (achiral analogues of the well-established chiral oligourea foldamers) to adopt helical conformations was explored spectroscopically. Up to four achiral units were ligated either to a well-formed helical trimer or to a single chiral diamine, and the extent to which they adopted a screw-sense preference was determined by NMR and CD. In the best performing cases, a trimeric chiral oligourea and even a single cis-cyclohexanediamine monomer induced folding into a helical conformation.

Graphical abstract: Inducing achiral aliphatic oligoureas to fold into helical conformations

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Publication details

The article was received on 29 Aug 2014, accepted on 14 Oct 2014 and first published on 14 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC06754A
Citation: Chem. Commun., 2014,50, 15006-15009
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    Inducing achiral aliphatic oligoureas to fold into helical conformations

    R. Wechsel, J. Maury, J. Fremaux, S. P. France, G. Guichard and J. Clayden, Chem. Commun., 2014, 50, 15006
    DOI: 10.1039/C4CC06754A

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