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Issue 83, 2014
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Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

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Abstract

Presented here is a solid phase chemical ligation strategy employing native chemical ligation and the commercially available Rink-amide linker as a key element in our approach. The method was applied for the synthesis of histone H2B, which sets the ground for the rapid preparation of posttranslationally modified analogues of this protein.

Graphical abstract: Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

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Publication details

The article was received on 18 Aug 2014, accepted on 30 Aug 2014 and first published on 08 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06499B
Citation: Chem. Commun., 2014,50, 12534-12537
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    Solid phase chemical ligation employing a rink amide linker for the synthesis of histone H2B protein

    M. Jbara, M. Seenaiah and A. Brik, Chem. Commun., 2014, 50, 12534
    DOI: 10.1039/C4CC06499B

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