Nanopore analysis has emerged as the simplest single-molecule technique. We combined DNA probes with a nanopore electrochemical sensor for the rapid and sensitive detection of pathogenic DNA. The novel nanopore biosensor allows the single-base discrimination and detection of picomolar DNA in serum samples.
F. Yao, Y. Zhang, Y. Wei and X. Kang, Chem. Commun., 2014, 50, 13853 DOI: 10.1039/C4CC06135G
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