An efficient and facile route to chiral tetrahydroquinolines with three contiguous stereogenic centers via a dynamic kinetic resolution process has been successfully developed by using chiral phosphoric acid as catalyst and Hantzsch ester as the hydrogen source with up to 89% ee.
M. Chen, X. Cai, Z. Chen, L. Shi and Y. Zhou, Chem. Commun., 2014, 50, 12526 DOI: 10.1039/C4CC06060A
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