Aurophilically cross-linked “dynamic” hydrogels mimicking healthy synovial fluid properties

Pablo Casuso; Adrián Pérez-San Vicente; Haizea Iribar; Araika Gutiérrez-Rivera; Ander Izeta; Iraida Loinaz; Germán Cabañero; Hans-Jürgen Grande; Ibon Odriozola; Damien Dupin

doi:10.1039/C4CC05735J

Aurophilically cross-linked “dynamic” hydrogels mimicking healthy synovial fluid properties†

Pablo Casuso,^a Adrián Pérez-San Vicente,^a Haizea Iribar,^b Araika Gutiérrez-Rivera,^b Ander Izeta,^b Iraida Loinaz,^a Germán Cabañero,^a Hans-Jürgen Grande,^a Ibon Odriozola*^a and Damien Dupin*^a

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^a Materials Division, IK4-CIDETEC Research Centre, Paseo Miramón 196, Donostia-San Sebastián 20009, Spain
E-mail: ddupin@cidetec.es, iodriozola@cidetec.es

^b Tissue Engineering Laboratory, Bioengineering Area, Instituto Biodonostia, Hospital Universitario Donostia, Paseo Dr. Begiristain s/n, 20014 San Sebastián, Spain

Abstract

We report a new supramolecular dynamic hydrogel, based on a new concept of reversible aurophilic cross-linkers, mimicking the rheological behaviour of healthy synovial fluid under physiological conditions with good cell viability.

Chemical Communications

Aurophilically cross-linked “dynamic” hydrogels mimicking healthy synovial fluid properties†

Abstract

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Aurophilically cross-linked “dynamic” hydrogels mimicking healthy synovial fluid properties

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