Issue 79, 2014

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Abstract

We herein report a fluorescent bimodal probe (1) capable of determining ER viscosity and polarity changes using FLIM and fluorescence ratiometry, respectively; during ER stress caused by tunicamycin, the viscosity was increased from ca. 129.5 to 182.0 cP and the polarity of the ER (dielectric constant, ε) enhanced from 18.5 to 21.1.

Graphical abstract: A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Supplementary files

Article information

Article type
Communication
Submitted
27 Jun 2014
Accepted
08 Aug 2014
First published
08 Aug 2014

Chem. Commun., 2014,50, 11672-11675

Author version available

A Nile Red/BODIPY-based bimodal probe sensitive to changes in the micropolarity and microviscosity of the endoplasmic reticulum

Z. Yang, Y. He, J. H. Lee, W. Chae, W. X. Ren, J. H. Lee, C. Kang and J. S. Kim, Chem. Commun., 2014, 50, 11672 DOI: 10.1039/C4CC04915B

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