An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature

Guobin Ma; Wen Wan; Jialiang Li; Qingyang Hu; Haizhen Jiang; Shizheng Zhu; Jing Wang; Jian Hao

doi:10.1039/C4CC04591B

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An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature†

Guobin Ma,^a Wen Wan,*^a Jialiang Li,^a Qingyang Hu,^a Haizhen Jiang,^a Shizheng Zhu,^b Jing Wang^a and Jian Hao*^ab

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* Corresponding authors

^a Department of Chemistry, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China
E-mail: jhao@shu.edu.cn, wanwen@staff.shu.edu.cn

^b Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China

Abstract

A mild, versatile and efficient method for the regioselective hydrodifluoromethylation of unactivated alkenes has been developed. This Ag-mediated Csp³–CF₂ bond forming reaction provides easy access to a variety of vicinal α-difluoroacetate-containing alkanes.

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Article information

DOI: https://doi.org/10.1039/C4CC04591B
Article type: Communication
Submitted: 17 Jun 2014
Accepted: 07 Jul 2014
First published: 08 Jul 2014

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Chem. Commun., 2014,50, 9749-9752

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An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF₂CO₂Et at ambient temperature

G. Ma, W. Wan, J. Li, Q. Hu, H. Jiang, S. Zhu, J. Wang and J. Hao, Chem. Commun., 2014, 50, 9749 DOI: 10.1039/C4CC04591B

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Chemical Communications