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Issue 68, 2014
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An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature

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Abstract

A mild, versatile and efficient method for the regioselective hydrodifluoromethylation of unactivated alkenes has been developed. This Ag-mediated Csp3–CF2 bond forming reaction provides easy access to a variety of vicinal α-difluoroacetate-containing alkanes.

Graphical abstract: An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature

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Publication details

The article was received on 17 Jun 2014, accepted on 07 Jul 2014 and first published on 08 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC04591B
Citation: Chem. Commun., 2014,50, 9749-9752
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    An efficient regioselective hydrodifluoromethylation of unactivated alkenes with TMSCF2CO2Et at ambient temperature

    G. Ma, W. Wan, J. Li, Q. Hu, H. Jiang, S. Zhu, J. Wang and J. Hao, Chem. Commun., 2014, 50, 9749
    DOI: 10.1039/C4CC04591B

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