Jump to main content
Jump to site search

Issue 63, 2014
Previous Article Next Article

Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library

Author affiliations

Abstract

From a γ-AApeptide-based one-bead-one-compound (OBOC) combinatorial library, we identified γ-AApeptides that can selectively inhibit STAT3–DNA interaction and suppress the expression levels of STAT3 target genes in intact cells. Our results demonstrate that in addition to the SH2 domain, the DNA binding domain of STAT3 is targetable for the development of a new generation of anti-cancer therapeutics.

Graphical abstract: Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library

Back to tab navigation

Supplementary files

Publication details

The article was received on 22 May 2014, accepted on 09 Jun 2014 and first published on 09 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03909B
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 8739-8742
  •   Request permissions

    Identification of novel inhibitors that disrupt STAT3–DNA interaction from a γ-AApeptide OBOC combinatorial library

    P. Teng, X. Zhang, H. Wu, Q. Qiao, S. M. Sebti and J. Cai, Chem. Commun., 2014, 50, 8739
    DOI: 10.1039/C4CC03909B

Search articles by author

Spotlight

Advertisements