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Issue 74, 2014
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A role of disordered domains in regulating protein oligomerization and stability

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Abstract

Intrinsically disordered proteins (IDPs) or regions (IDRs) in proteins hold many functions but their biological roles are still not fully understood. Here we describe a new role of such regions. Using the HIV-1 Rev protein, we show that disordered domains have a role in maintaining the correct oligomeric state and the thermodynamic stability of proteins.

Graphical abstract: A role of disordered domains in regulating protein oligomerization and stability

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Publication details

The article was received on 20 May 2014, accepted on 15 Jul 2014 and first published on 15 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03863K
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 10797-10800
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    A role of disordered domains in regulating protein oligomerization and stability

    O. Faust, L. Bigman and A. Friedler, Chem. Commun., 2014, 50, 10797
    DOI: 10.1039/C4CC03863K

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