Issue 55, 2014
From the journal:

Chemical Communications

Zinc-mediated CH-activation of tetrahydrofuran under mild conditions for the regioselective addition to aryl-propiolates†

Florian Pünnera  and  Gerhard Hilt*a  

* Corresponding authors

a Fachbereich Chemie, Hans-Meerwein-Str., 35043 Marburg, Germany
E-mail: Hilt@chemie.uni-marburg.de
Fax: +49 6421 2825677
Tel: +49 6421 2825601

Abstract

The CH-activation of THF is realized in a zinc-mediated process using a dibromocyclopropane as a crucial additive. The highly regioselective addition to aryl-substituted propiolates as well as the regio- and stereoselective addition to diynes are described.

Graphical abstract: Zinc-mediated CH-activation of tetrahydrofuran under mild conditions for the regioselective addition to aryl-propiolates

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Article information

DOI
https://doi.org/10.1039/C4CC03348E
Article type
Communication
Submitted
05 May 2014
Accepted
20 May 2014
First published
21 May 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 7310-7313

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Zinc-mediated CH-activation of tetrahydrofuran under mild conditions for the regioselective addition to aryl-propiolates

F. Pünner and G. Hilt, Chem. Commun., 2014, 50, 7310 DOI: 10.1039/C4CC03348E

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