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Issue 56, 2014
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Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

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Abstract

A copper-mediated gem-difluoromethylenation of aryl, heteroaryl and vinyl boronic acids with bromodifluoromethylated oxazole or thiazole derivatives has been developed. This novel reaction showed an excellent functional group tolerance and wide substrate scope, providing facile access to practical application in drug discovery and development.

Graphical abstract: Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

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Publication details

The article was received on 04 May 2014, accepted on 20 May 2014 and first published on 03 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03321C
Citation: Chem. Commun., 2014,50, 7527-7530
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    Highly effective copper-mediated gem-difluoromethylenation of arylboronic acids

    G. Ma, W. Wan, Q. Hu, H. Jiang, J. Wang, S. Zhu and J. Hao, Chem. Commun., 2014, 50, 7527
    DOI: 10.1039/C4CC03321C

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