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Issue 73, 2014
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The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

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Abstract

Au25 clusters stabilized by tridecapeptides were firstly synthesized, which can well penetrate the cell membrane and exactly locate in the cytoplasm. Hence the Au clusters significantly suppress the TrxR1 activity in the cytoplasm, and further induce the up-regulation of the activated PARP level which allows the tumor cell apoptosis to occur in a Au dose dependent manner.

Graphical abstract: The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

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Publication details

The article was received on 04 May 2014, accepted on 23 Jul 2014 and first published on 23 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03320E
Citation: Chem. Commun., 2014,50, 10687-10690
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    The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity

    R. Liu, Y. Wang, Q. Yuan, D. An, J. Li and X. Gao, Chem. Commun., 2014, 50, 10687
    DOI: 10.1039/C4CC03320E

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