Issue 50, 2014
From the journal:

Chemical Communications

A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation†

Nam-Young Kang,‡a   Sung-Jin Park,‡a   Xiao Wei Emmiline Ang,a   Animesh Samanta,a   Wouter H. P. Driessen,b   Vasilis Ntziachristos,c   Kristine O. Vasquez,d   Jeffrey D. Peterson,d   Seong-Wook Yun*a  and  Young-Tae Chang*ae  

* Corresponding authors

a Singapore Bioimaging Consortium, Agency for Science, Technology and Research, 11 Biopolis Way, # 02-02 Helios, Singapore 138667, Singapore
E-mail: yun_seong_wook@sbic.a-star.edu.sg

b iThera Medical, GmbH, Munich, Germany

c Institute for Biological and Medical Imaging (IBMI), Helmholtz Centre Munich Chair of Biological Imaging (CBI), Technische Universität Munich, Germany

d Life Sciences & Technology, PerkinElmer, Inc, Boston, Massachusetts, USA

e Department of Chemistry & Med Chem Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore
E-mail: chmcyt@nus.edu.sg
Web: http://ytchang.science.nus.edu.sg

Abstract

Visualization of macrophages in live animals has been of great interest for a better understanding of inflammation. We developed a near infrared (NIR) probe CDnir7 that can selectively detect macrophages and visualize inflammation in vivo using the IVIS spectrum, Fluorescence Molecular Tomography (FMT) and Multi-Spectral Optoacoustic Tomography (MSOT).

Graphical abstract: A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation

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Article information

DOI
https://doi.org/10.1039/C4CC02038C
Article type
Communication
Submitted
19 Mar 2014
Accepted
02 May 2014
First published
13 May 2014

Chem. Commun., 2014,50, 6589-6591

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A macrophage uptaking near-infrared chemical probe CDnir7 for in vivo imaging of inflammation

N. Kang, S. Park, X. W. E. Ang, A. Samanta, W. H. P. Driessen, V. Ntziachristos, K. O. Vasquez, J. D. Peterson, S. Yun and Y. Chang, Chem. Commun., 2014, 50, 6589 DOI: 10.1039/C4CC02038C

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