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Issue 36, 2014
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Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

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Abstract

We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors.

Graphical abstract: Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

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Publication details

The article was received on 19 Feb 2014, accepted on 13 Mar 2014 and first published on 17 Mar 2014


Article type: Communication
DOI: 10.1039/C4CC01290A
Citation: Chem. Commun., 2014,50, 4690-4692
  • Open access: Creative Commons BY-NC license
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    Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

    A. McQuistan, A. J. Zaitouna, E. Echeverria and R. Y. Lai, Chem. Commun., 2014, 50, 4690
    DOI: 10.1039/C4CC01290A

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