Issue 33, 2014
From the journal:

Chemical Communications

Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent†

Guojing Ji,ab   Xi Wang,*a   Songnan Zhang,a   Yan Xu,a   Yuxuan Ye,a   Ming Li,b   Yan Zhanga  and  Jianbo Wang*a  

* Corresponding authors

a Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China
E-mail: wangjb@pku.edu.cn

b College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China

Abstract

A mild and efficient method for the synthesis of 3-trifluoromethylpyrazoles has been established via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent under transition-metal-free conditions.

Graphical abstract: Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

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Article information

DOI
https://doi.org/10.1039/C4CC01280A
Article type
Communication
Submitted
18 Feb 2014
Accepted
04 Mar 2014
First published
05 Mar 2014

Chem. Commun., 2014,50, 4361-4363

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Synthesis of 3-trifluoromethylpyrazoles via trifluoromethylation/cyclization of α,β-alkynic hydrazones using a hypervalent iodine reagent

G. Ji, X. Wang, S. Zhang, Y. Xu, Y. Ye, M. Li, Y. Zhang and J. Wang, Chem. Commun., 2014, 50, 4361 DOI: 10.1039/C4CC01280A

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