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Issue 45, 2014
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Design of tetraplex specific ligands: cyclic naphthalene diimide

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Abstract

Cyclic naphthalene diimide 1 bound to hybrid-type tetraplex DNA from 5′-AGGG(TTAGGG)3-3′ (K = 8.6 × 106 M−1) with 260-fold greater affinity than binding to a double stranded oligonucleotide consisting of 5′-GGG AGG TTT CGC-3′ and 3′-CCC TCC AAA GCG-5′ (nK = 3.3 × 104 M−1) with 0.5 μM of IC50 for telomerase activity.

Graphical abstract: Design of tetraplex specific ligands: cyclic naphthalene diimide

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Publication details

The article was received on 07 Feb 2014, accepted on 11 Apr 2014 and first published on 11 Apr 2014


Article type: Communication
DOI: 10.1039/C4CC01005A
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 5967-5969
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    Design of tetraplex specific ligands: cyclic naphthalene diimide

    Y. Esaki, Md. M. Islam, S. Fujii, S. Sato and S. Takenaka, Chem. Commun., 2014, 50, 5967
    DOI: 10.1039/C4CC01005A

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