Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp3)–H bonds with aryl halides

Mingliang Li; Jiaxing Dong; Xiaolei Huang; Kaizhi Li; Qian Wu; Feijie Song; Jingsong You

doi:10.1039/C4CC00716F

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Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp³)–H bonds with aryl halides†

Mingliang Li,^a Jiaxing Dong,^a Xiaolei Huang,^a Kaizhi Li,^a Qian Wu,^a Feijie Song^a and Jingsong You*^a

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* Corresponding authors

^a Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, and State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China
E-mail: jsyou@scu.edu.cn
Fax: +86 28-85412203

Abstract

In this work, we have disclosed the nickel-catalyzed unactivated β-C(sp³)–H bond arylation of aliphatic acid derivatives with aryl iodides/bromides via bidentate chelation-assistance of an 8-aminoquinoline moiety. These preliminary results indicate the intrinsic catalytic potential of nickel metal for unactivated C(sp³)–H bond arylation.

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Article information

DOI: https://doi.org/10.1039/C4CC00716F
Article type: Communication
Submitted: 27 Jan 2014
Accepted: 19 Feb 2014
First published: 19 Feb 2014

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Chem. Commun., 2014,50, 3944-3946

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Nickel-catalyzed chelation-assisted direct arylation of unactivated C(sp³)–H bonds with aryl halides

M. Li, J. Dong, X. Huang, K. Li, Q. Wu, F. Song and J. You, Chem. Commun., 2014, 50, 3944 DOI: 10.1039/C4CC00716F

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