Controlling leucine-zipper partner recognition in cells through modification of a–g interactions

Yusuke Azuma; Tim Kükenshöner; Guangyong Ma; Jun-ichiro Yasunaga; Miki Imanishi; Gen Tanaka; Ikuhiko Nakase; Takahiro Maruno; Yuji Kobayashi; Katja M. Arndt; Masao Matsuoka; Shiroh Futaki

doi:10.1039/C4CC00555D

Controlling leucine-zipper partner recognition in cells through modification of a–g interactions†

Yusuke Azuma,^a Tim Kükenshöner,^b Guangyong Ma,^c Jun-ichiro Yasunaga,^c Miki Imanishi,^a Gen Tanaka,^a Ikuhiko Nakase,^a Takahiro Maruno,^d Yuji Kobayashi,^d Katja M. Arndt,*^b Masao Matsuoka*^c and Shiroh Futaki*^a

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* Corresponding authors

^a Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
E-mail: futaki@scl.kyoto-u.ac.jp
Fax: +81-774-32-3038
Tel: +81-774-38-3210

^b Institute for Biochemistry and Biology, University of Potsdam, 14476 Potsdam-Golm, Germany
E-mail: katja.arndt@uni-potsdam.de

^c Institute for Virus Research, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan
E-mail: mmatsuok@virus.kyoto-u.ac.jp

^d Graduate School of Engineering, Osaka University, Suita, Japan

Abstract

By focusing on the a–g interactions, successful design and selection were accomplished to obtain a leucine-zipper segment that discriminates the appropriate partner over another that provides very similar patterns of electrostatic interactions.

Chemical Communications

Controlling leucine-zipper partner recognition in cells through modification of a–g interactions†

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Controlling leucine-zipper partner recognition in cells through modification of a–g interactions

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