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Issue 24, 2014
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Cu-catalyzed amidation of halogenated imidazoles

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Abstract

An efficient methodology involving the Cu-catalyzed amidation of halogenated imidazoles has been successfully developed. The amidated product of 5-bromo-1-alkylimidazole was further applied to the synthesis of a new chiral imidazole nucleophilic catalyst for the kinetic resolution of secondary alcohols.

Graphical abstract: Cu-catalyzed amidation of halogenated imidazoles

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Publication details

The article was received on 29 Nov 2013, accepted on 17 Jan 2014 and first published on 22 Jan 2014


Article type: Communication
DOI: 10.1039/C3CC49107B
Citation: Chem. Commun., 2014,50, 3163-3165
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    Cu-catalyzed amidation of halogenated imidazoles

    M. Wang, Z. Zhang, F. Xie and W. Zhang, Chem. Commun., 2014, 50, 3163
    DOI: 10.1039/C3CC49107B

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