Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 40, 2014
Previous Article Next Article

A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

Author affiliations

Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)–amyloid-β (Aβ) over Zn(II)–Aβ.

Graphical abstract: A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 06 Nov 2013, accepted on 20 Nov 2013 and first published on 10 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48473D
Citation: Chem. Commun., 2014,50, 5301-5303
  •   Request permissions

    A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

    M. G. Savelieff, Y. Liu, R. R. P. Senthamarai, K. J. Korshavn, H. J. Lee, A. Ramamoorthy and M. H. Lim, Chem. Commun., 2014, 50, 5301
    DOI: 10.1039/C3CC48473D

Search articles by author