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Issue 40, 2014
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A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

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Abstract

Alzheimer's disease (AD) is a complex, multifactorial, neurodegenerative disease that poses tremendous difficulties in pinpointing its precise etiology. A toolkit, which specifically targets and modulates suggested key players, may elucidate their roles in disease onset and progression. We report high-resolution insights on the activity of a small molecule (L2-NO) which exhibits reactivity toward Cu(II)–amyloid-β (Aβ) over Zn(II)–Aβ.

Graphical abstract: A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

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The article was received on 06 Nov 2013, accepted on 20 Nov 2013 and first published on 10 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC48473D
Author version available: Download Author version (PDF)
Citation: Chem. Commun., 2014,50, 5301-5303
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    A small molecule that displays marked reactivity toward copper– versus zinc–amyloid-β implicated in Alzheimer's disease

    M. G. Savelieff, Y. Liu, R. R. P. Senthamarai, K. J. Korshavn, H. J. Lee, A. Ramamoorthy and M. H. Lim, Chem. Commun., 2014, 50, 5301
    DOI: 10.1039/C3CC48473D

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