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Issue 8, 2014
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Remote chirality control based on the organocatalytic asymmetric Mannich reaction of α-thio acetaldehydes

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Abstract

Remote chirality control leading to 1,4-difunctionalized compounds such as 1,4-amino alcohols and 1,4-diamines was achieved by both syn- and anti-selective asymmetric Mannich reactions of α-thio acetaldehydes, the subsequent olefination and the stereospecific 2,3-sigmatropic rearrangement.

Graphical abstract: Remote chirality control based on the organocatalytic asymmetric Mannich reaction of α-thio acetaldehydes

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The article was received on 11 Oct 2013, accepted on 11 Nov 2013 and first published on 11 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47827K
Citation: Chem. Commun., 2014,50, 942-944
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    Remote chirality control based on the organocatalytic asymmetric Mannich reaction of α-thio acetaldehydes

    T. Kano, R. Sakamoto and K. Maruoka, Chem. Commun., 2014, 50, 942
    DOI: 10.1039/C3CC47827K

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