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Issue 9, 2014
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Nanobioprobe mediated DNA aptamers for explosive detection

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Abstract

Specific nucleic acid aptamers using the microtiter plate based modified SELEX method against explosive trinitrotoluene are reported. Efficient partitioning of dsDNA was carried out using streptavidin labeled gold nanoprobes for the selection of specific aptamers. The selected binders having an affinity of ∼10−7 M were used in the newly developed electrochemical aptasensor, exhibiting a detection limit of around 1 ppb for trinitrotoluene.

Graphical abstract: Nanobioprobe mediated DNA aptamers for explosive detection

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Publication details

The article was received on 02 Oct 2013, accepted on 19 Nov 2013 and first published on 19 Nov 2013


Article type: Communication
DOI: 10.1039/C3CC47562J
Citation: Chem. Commun., 2014,50, 1080-1082
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    Nanobioprobe mediated DNA aptamers for explosive detection

    Priyanka, M. Shorie, V. Bhalla, P. Pathania and C. R. Suri, Chem. Commun., 2014, 50, 1080
    DOI: 10.1039/C3CC47562J

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