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Issue 40, 2014
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Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

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Abstract

A method for monitoring in vitro polyketide synthesis has been developed whereby nonchromophoric polyketide products are made brightly fluorescent in a simple, rapid, inexpensive, and bioorthogonal manner through CuAAC with a sulforhodamine B azide derivative.

Graphical abstract: Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

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Publication details

The article was received on 01 Oct 2013, accepted on 29 Oct 2013 and first published on 29 Oct 2013


Article type: Communication
DOI: 10.1039/C3CC47513A
Citation: Chem. Commun., 2014,50, 5276-5278
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    Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

    A. J. Hughes, M. R. Tibby, D. T. Wagner, J. N. Brantley and A. T. Keatinge-Clay, Chem. Commun., 2014, 50, 5276
    DOI: 10.1039/C3CC47513A

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