Issue 12, 2014

Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

Abstract

We report preliminary findings suggesting that the diameter of the internalised calcium phosphate particles is critical to cell fate with particles/aggregates of particles of larger than 1.5 μm not processed by lysosomes leading to cell death. This has significant implications for the design of medical materials even from those consisting of non-toxic calcium phosphate salts.

Graphical abstract: Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

Supplementary files

Article information

Article type
Communication
Submitted
09 Jul 2014
Accepted
18 Jul 2014
First published
05 Aug 2014

Biomater. Sci., 2014,2, 1723-1726

Author version available

Quantification of volume and size distribution of internalised calcium phosphate particles and their influence on cell fate

R. L. Williams, I. Vizcaíno-Castón and L. M. Grover, Biomater. Sci., 2014, 2, 1723 DOI: 10.1039/C4BM00238E

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