Issue 11, 2014

The instructive role of the vasculature in stem cell niches

Abstract

An important hallmark of many adult stem cell niches is their proximity to the vasculature in vivo, a feature common to neural stem cells (NSCs), mesenchymal stem cells (MSCs) from bone marrow, adipose, and other tissues, hematopoietic stem cells (HSCs), and many tumor stem cells. This review summarizes key studies supporting the vasculature's instructive role in adult stem cell niches, and the putative underlying molecular mechanisms by which blood vessels in these niches exert control over progenitor cell fates. The importance of the perivascular niche for pathology, notably tumor metastasis and dormancy, is also highlighted. Finally, the implications of the perivascular regulation of stem and progenitor cells on biomaterial design and the impact on future research directions are discussed.

Graphical abstract: The instructive role of the vasculature in stem cell niches

Article information

Article type
Review Article
Submitted
03 Jun 2014
Accepted
29 Jul 2014
First published
06 Aug 2014

Biomater. Sci., 2014,2, 1562-1573

The instructive role of the vasculature in stem cell niches

A. J. Putnam, Biomater. Sci., 2014, 2, 1562 DOI: 10.1039/C4BM00200H

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