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Issue 14, 2015
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A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

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Abstract

Ubiquitination is of great importance as the post-translational modification of proteins with ubiquitin, or ubiquitin chains, facilitates a number of vital cellular processes. Herein we present a facile method of preparing various ubiquitin conjugates under mild conditions using michael acceptors based on dibromo-maleimides and dibromo-pyridazinediones.

Graphical abstract: A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

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Publication details

The article was received on 22 Jan 2015, accepted on 24 Feb 2015 and first published on 24 Feb 2015


Article type: Communication
DOI: 10.1039/C5OB00130G
Citation: Org. Biomol. Chem., 2015,13, 4165-4168
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    A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation

    R. E. Morgan, V. Chudasama, P. Moody, M. E. B. Smith and S. Caddick, Org. Biomol. Chem., 2015, 13, 4165
    DOI: 10.1039/C5OB00130G

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