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Issue 40, 2013
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Attaching double chain cationic Gd(III)-containing surfactants on nanosized colloids for highly efficient MRI contrast agents

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Abstract

A new Gd(III)-based metallosurfactant with double quaternary-ammonium-containing long alkyl chains was developed and subjected to the miniemulsion polymerization of vinyl monomers, giving nanosized colloids (50–110 nm) with narrow size distribution. The size of the colloid particles can be easily tuned by adjusting the feeding ratio of metallosurfactant to monomer. SEM and XPS analysis showed that the Gd(III) complexes were attached on the surface of the colloids. ICP-AES analysis further quantified the contents of Gd(III) in the miniemulsions. T1 magnetic resonance imaging (MRI) showed that these Gd(III)-loading colloids exhibited relaxivity of up to 22.77 mM−1 s−1, much higher than that of Ominiscan® (4.64 mM−1 s−1).

Graphical abstract: Attaching double chain cationic Gd(iii)-containing surfactants on nanosized colloids for highly efficient MRI contrast agents

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Publication details

The article was received on 06 Jun 2013, accepted on 06 Aug 2013 and first published on 07 Aug 2013


Article type: Paper
DOI: 10.1039/C3TB20807A
Citation: J. Mater. Chem. B, 2013,1, 5443-5449
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    Attaching double chain cationic Gd(III)-containing surfactants on nanosized colloids for highly efficient MRI contrast agents

    Y. Chen, H. Yang, W. Tang, X. Cui, W. Wang, X. Chen, Y. Yuan and A. Hu, J. Mater. Chem. B, 2013, 1, 5443
    DOI: 10.1039/C3TB20807A

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