Jump to main content
Jump to site search

Issue 33, 2013
Previous Article Next Article

Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering

Author affiliations

Abstract

This study focused on the design of novel mechanically tough, biocompatible, osteoconductive and biodegradable scaffolds based on sunflower oil modified hyperbranched polyurethane (HBPU)/functionalized multi-walled carbon nanotube (f-MWCNT) nanocomposites (NCs), and the response of an animal model on their post-implantation. The NC was prepared by an in situ polymerization technique with different wt% of f-MWCNTs. The tensile strength of the NCs was enhanced to 36.98–47.6 MPa from 23.93 MPa (HBPU) and toughness from 12 767 to 18 427–19 440 due to the addition and efficient dispersion of the f-MWCNTs in the HBPU matrix. The post-60 days in vitro biodegraded NC retained sufficient strength (39 ± 1.65 MPa). The increase in wt% of f-MWCNTs had a significant effect on tailoring the physico-mechanical properties of the polymer. The hematological, histological and immunological indices of toxicity suggested the safety potential of the prepared systems within the tested animal model. Moreover, the cytokines (viz. IL-6 and TNF-α) detection, MTT assay and anti-hemolytic assay boosted the non-toxic behavior of the systems. The NC with interconnected pores size (200–330 μm) showed better proliferation and adherence of osteoblast (MG63) cells compared to the HBPU and the results were comparable with the control. Thus the findings confirmed the non-toxicity of f-MWCNTs in association with the polymer and thereby endorsed the NC as a potential biomimetic scaffold for bone tissue engineering.

Graphical abstract: Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering

Back to tab navigation

Publication details

The article was received on 16 May 2013, accepted on 19 Jun 2013 and first published on 20 Jun 2013


Article type: Paper
DOI: 10.1039/C3TB20693A
Citation: J. Mater. Chem. B, 2013,1, 4115-4126
  •   Request permissions

    Nanocomposites of bio-based hyperbranched polyurethane/funtionalized MWCNT as non-immunogenic, osteoconductive, biodegradable and biocompatible scaffolds in bone tissue engineering

    B. Das, P. Chattopadhyay, D. Mishra, T. K. Maiti, S. Maji, R. Narayan and N. Karak, J. Mater. Chem. B, 2013, 1, 4115
    DOI: 10.1039/C3TB20693A

Search articles by author

Spotlight

Advertisements