Issue 10, 2013
From the journal:

Journal of Materials Chemistry B

Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound†

Eoghan Dillon,a   Manoop S. Bhutanib  and  Andrew R. Barron*acd  

* Corresponding authors

a Department of Chemistry, Rice University, Houston, Texas 77005, USA
E-mail: arb@rice.edu
Tel: +1 713 348 5610

b Department of Gastroenterology, Hepatology, and Nutrition, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA
E-mail: Manoop.Bhutani@mdanderson.org
Tel: +1 713 794 5073

c Department of Mechanical Engineering and Materials Science, Rice University, Houston, Texas 77005, USA

d College of Engineering, Swansea University, Singleton Park, Swansea SA2 8PP, Wales, UK

Abstract

Water soluble polyethyleneimine functionalized single wall carbon nanotubes (PEI–SWNTs) can be loaded with the therapeutic agents acetic acid and the gemcitabine analogue, deoxycytidine (dC). The amount of loading is based on initial sonication time and the solubility of the agent. The use of an endoscopic ultrasound (EUS) results in the controlled release of the agents from the PEI–SWNT conjugate. The release of acetic acid occurs by first-order kinetics, however, the release of the majority of the dC occurs by the more desired zero-order release.

Graphical abstract: Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound

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Article information

DOI
https://doi.org/10.1039/C3TB00456B
Article type
Paper
Submitted
25 Nov 2012
Accepted
17 Jan 2013
First published
21 Jan 2013

J. Mater. Chem. B, 2013,1, 1461-1465

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Small molecule capture and release from PEI-functionalized single walled carbon nanotubes with endoscopic ultrasound

E. Dillon, M. S. Bhutani and A. R. Barron, J. Mater. Chem. B, 2013, 1, 1461 DOI: 10.1039/C3TB00456B

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