Structural characterisation of hypoxia-mimicking bioactive glasses†
Abstract
Nickel and cobalt are both known to stimulate the hypoxia-inducible factor-1 (HIF-1α), thus significantly improving blood vessel formation in tissue engineering applications. We have manufactured nickel and cobalt doped bioactive glasses to act as a controlled delivery mechanism of these ions. The resultant structural consequences have been investigated using the methods of isotopic and isomorphic substitution applied to