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Issue 46, 2013
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Net motion of a charged macromolecule in a ratchet-slit

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Abstract

Hydrodynamic effects in a ratchet channel may produce counterintuitive phenomena. We report herein a net motion investigation of a charged macromolecule in a ratchet-slit under an AC electric field using explicit solvent molecular dynamics. A negative net motion was discovered and complex responses to the slit structure, external electric field and charge distribution were explored. It has been demonstrated that the complex responses originate from the competition among three ratchet forces in the diffusion of macromolecules, i.e. the entropy force, solvent dissipative force and conformation inversion resistance (the first force produces positive net motion, while the other two contribute to the negative net motion together). This new transport mechanism can be applied to developing novel effective techniques for the separation of bio-macromolecules with different charge sequences.

Graphical abstract: Net motion of a charged macromolecule in a ratchet-slit

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Publication details

The article was received on 25 Jul 2013, accepted on 01 Oct 2013 and first published on 01 Oct 2013


Article type: Paper
DOI: 10.1039/C3SM52011K
Citation: Soft Matter, 2013,9, 11107-11112
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    Net motion of a charged macromolecule in a ratchet-slit

    Z. Wang, Z. Jia and X. He, Soft Matter, 2013, 9, 11107
    DOI: 10.1039/C3SM52011K

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